(+)-3-Methylcyclohexanone → HCID 69221234, compound

HRID 2374196Notes

Reaction equation

HRID 2374196 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1)#[CH:2].[CH3:9][C@@H:10]1[CH2:15][CH2:14][CH2:13][C:12](=O)[CH2:11]1>>[CH3:9][C@H:10]1[CH2:11][C:12]([C:2]#[C:1][C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=2)=[CH:13][CH2:14][CH2:15]1.[CH3:9][C@@H:10]1[CH2:15][CH2:14][CH2:13][C:12]([C:2]#[C:1][C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=2)=[CH:11]1

Participants

4

Reactant 2

HCID 83384(+)-3-MethylcyclohexanoneHCID 137268Ethynylpyridine

Product 2

HCID 69221234HCID 69221234, compoundHCID 69221747HCID 69221747, compound

Procedure

Reactants: 2-ethynylpyridine (6.0 mmol, 618 mg), (3R)-(+)-3-methylcyclohexanone (6.0 mmol, 0.73 mL); yields 2-{[(5R)-5-methyl-1-cyclohexen-1-yl]ethynyl}pyridine and 2-{[(3R)-3-methyl-1-cyclohexen-1-yl]ethynyl}pyridine (1:1) as a transparent yellow oil (440 mg, 37% overall yield) as a mixture of regioisomers. 1H NMR (CDCl3, 300 MHz) Δ8.56 (m, 1H), 7.62 (m, 1H), 7.40 (m, 1H), 7.18 (m, 1H), 6.31 (m, 0.5H), 6.19 (m, 0.5H), 2.30 (m, 3H), 1.85 (m, 2.5H), 1.22 (m, 1H), 0.98 (m, 3.5H). MS (EI ionization) 197 (M+) two peaks resolved.

Sources & evidence

ORD record
ord-740643dce1d04aebbd7cddab645411e4
Source dataset
uspto-grants-2008_12
Patent number
US07462619B2

Reaction notes

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