Dichloromethane → HCID 9899683, compound

HRID 2374204Notes

Reaction equation

HRID 2374204 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH:15]=[N:14][CH:13]=[C:12]([CH3:16])[N:11]=2)[CH:5]=[CH:6][CH:7]=1.C(Cl)[Cl:18]>C(OCC)C>[ClH:18].[F:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH:15]=[N:14][CH:13]=[C:12]([CH3:16])[N:11]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 9899684HCID 9899684, compound

Product 1

HCID 9899683HCID 9899683, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

2-[(3-Fluorophenyl)ethynyl]-6-methylpyrazine (520 mg, 2.45 mmol) was dissolved in CH2Cl2 (3 mL), and the resulting solution was treated with HC1 in diethyl ether (2.7 mL of a 1.0M solution, 2.7 mmol). The mixture was sonicated, and the solvent decanted. The remaining solid was dried under high vacuum to afford 2-[(3-fluorophenyl)ethynyl]-6-methylpyrazine hydrochloride (338 mg, 60% yield) as a light yellow solid. M.p. 62-63° C. 1H NMR (CDCl3, 300 MHz) Δ8.73 (s, 1H), 8.57 (s, 1H), 7.54-7.35 (m, 3H), 7.28-7.20 (m, 3H), 2.84 (s, 3H).

Workup

  1. customThe mixture was sonicated
  2. customthe solvent decanted
  3. customThe remaining solid was dried under high vacuum

Sources & evidence

ORD record
ord-8c95aa55516e4049aca71cadb0bbae62
Source dataset
uspto-grants-2008_12
Patent number
US07462619B2

Reaction notes

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