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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2374210Generated: October 31, 2026

Potassium Fluoride → HCID 10156609, compound

https://huagongshe.com/reaction/2374210

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium FluorideHCID 522689—
Reactant2-Fluorophenylpropyl mesylateHCID 12071461—
ReactantHCID 135797776HCID 135797776—
SolventAcetonitrileHCID 6342—
ProductHCID 10156609HCID 10156609—

Reaction Conditions

Temperature80 °C

Reaction Steps

A suspension of 1.0 g (4.09 mmol) of 7-hydroxy-2-(pyridin-4-yl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one and 0.95 g (4.09 mmol) of 1-[3-(methylsulfonyloxy)propyl]-2-fluorobenzene in 100 ml of anhydrous acetonitrile was treated with 4.1 g (1.42 mmol) of potassium fluoride suspended on alumina (Fluka) and the resulting mixture was heated at 80° C. for 24 h.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07462621B2
Source datasetuspto-grants-2008_12
ORD IDord-4a742cac403849d6afbb245937318933
Source noteuspto-grants-2008_12