HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2,2-Dimethyl-7-(pyridin-4-yl)-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl 3-(4-pyridyl)-3-oxopropionate | HCID 2735202 | — |
| Reactant | 5,5-dimethyl-4,5-dihydro-1H-imidazol-2-amine hydrobromide | HCID 17851060 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2,2-Dimethyl-7-(pyridin-4-yl)-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-5-one | HCID 135811700 | — |
Reaction Steps
A suspension of 4.5 g (23.2 mmol) of 5,5-dimethyl-4,5-dihydro-1H-imidazol-2-ylamine hydrobromide, 2.99 g (15.46 mmol) of ethyl 3-(pyridin-4-yl)-3-oxopropionate and 4.27 g (30.89 mmol) of potassium carbonate in 100 ml of ethanol was heated at reflux temperature for 18 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07462621B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-982ea7b3524c458798da09c25cf90bd7 |
| Source note | uspto-grants-2008_12 |