Lithium Hydroxide → HCID 178440046, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of phosphonate 31 (11 mg, 0.015 mmol) in CH3CN (0.5 mL) was added 1N LiOH (46 μL, 0.046 mmol) at 0° C. See Scheme 21 (FIG. 23). After the reaction mixture was stirred for 2 h at 0° C., Dowex 50WX8-200 (26 mg) was added and stirring was continued for an additional 30 min. The reaction mixture was filtered, rinsed with CH3CN, and concentrated under reduced pressure to give {2-[5-(3,5-dichloro-phenylsulfanyl)-4-isopropyl-1-pyridin-4-ylmethyl-1H-imidazol-2-ylmethoxycarbonylamino]-ethyl }-phosphonic acid monophenyl ester 32 (10 mg, 100%) as a colorless oil. 1H NMR (300 MHz, CD3OD) δ 8.52 (d, 2H), 7.28 (m, 6H), 6.79 (m, 4H), 5.60 (s, 2H), 5.29 (s, 2H), 3.29 (m, 3H), 1.83 (m, 2H), 1.31 (d, 6H). 31P NMR (300 MHz, CD3OD) δ 20.2.

Provenance & Evidence