Potassium Hydroxide → HCID 15491245, compound

HRID 2374226Notes

Reaction equation

HRID 2374226 reaction equation
C([O:4][CH2:5][C:6]1[CH:7]=[C:8]([NH:13][C:14]([C:16]2[CH:20]=[CH:19][O:18][C:17]=2[CH3:21])=[O:15])[CH:9]=[CH:10][C:11]=1[Cl:12])(=O)C.[OH-].[K+]>O>[Cl:12][C:11]1[CH:10]=[CH:9][C:8]([NH:13][C:14]([C:16]2[CH:20]=[CH:19][O:18][C:17]=2[CH3:21])=[O:15])=[CH:7][C:6]=1[CH2:5][OH:4]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 22133219HCID 22133219, compound

Product 1

HCID 15491245HCID 15491245, compoundYield 94.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
70 °C

Procedure

A solution of 29 g of the N-(3-acetoxymethyl-4-chlorophenyl)-2-methyl-3-furancarboxamide prepared in Step 4 above and 14.5 g potassium hydroxide in 110 mL water, was prepared. The solution was then heated at 70° C. for 16 hours and then acidified with 2N hydrochloric. The resulting solid was collected, washed with water, and dried, producing 23.65 g of N-(4-chloro-3-hydroxymethylphenyl)-2-methyl-3-furancarboxamide as a white solid.

Workup

  1. customThe resulting solid was collected
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-9c5e0dc362ba4ae594969f5de7cac8e2
Source dataset
uspto-grants-2008_12
Patent number
US07462608B2

Reaction notes

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