HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 237423Generated: October 31, 2026
Potassium Carbonate → 1-(2-chloro-pyrimidin-4-yl)-4-(3-methanesulfonyl-propoxy)-1H-indole
https://huagongshe.com/reaction/237423
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 2,4-Dichloropyrimidine | HCID 77531 | — |
| Reactant | 4-(3-methanesulfonyl-propoxy)-1H-indole | HCID 58017092 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 1-(2-chloro-pyrimidin-4-yl)-4-(3-methanesulfonyl-propoxy)-1H-indole | HCID 58017080 | 94% |
Reaction Steps
4-(3-Methanesulfonyl-propoxy)-1H-indole (188.1 g), 2,4-dichloropyrimidine (221.25 g), HOBT (20.08 g), K2CO3 (143.68 g) and DMA (1.6 L) were heated to 85° C. for 20 h. IPA (5 was then added and the mixture was stirred for 20 min, then cooled to 0° C. for 3 h and filtered. The collected solid was rinsed with IPA and water, and the solid was dried in vacuo at 55° C. for 4 days to yield 1-(2-chloro-pyrimidin-4-yl)-4-(3-methanesulfonyl-propoxy)-1H-indole (94%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08642601B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-b2cec9eacf5049e1b3e43e2be50e8405 |
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| Source note | uspto-grants-2014_02 |
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