HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-4-nitrobenzotrifluoride → 5-Nitro-2-(trifluoromethyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-4-nitrobenzotrifluoride | HCID 10655830 | — |
| Reactant | Acetic acid sulfuric acid water | HCID 86597087 | — |
| Catalyst | chromium (VI) trioxide | HCID 10219390 | — |
| Product | 5-Nitro-2-(trifluoromethyl)benzoic acid | HCID 59853718 | — |
Reaction Steps
5-Nitro-2-trifluoromethyl-benzoic acid is prepared from the known 2-methyl-4-nitro-1-trifluoromethyl-benzene by oxidation with chromium trioxide in an acetic acid/water/sulfuric acid mixture following a procedure described by Aeberli et al. [P. Aeberli, P. Eden, J. H. Gogerty, W. J. Houlihan, C. Penberthy, J. Med. Chem. 18, 177 (1975)]: colourless solid, MS (ISN): 233.9 M−H−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07462617B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-4ed54f3ecd8f40979db0216607e42e97 |
| Source note | uspto-grants-2008_12 |