Hydrochloric Acid → 4-(methylsulfonyl)-Biphenyl-2-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

To 4-Methanesulfonyl-biphenyl-2-carboxylic acid methyl ester (1.00 g, 3.44 mmol) in 5 ml THF was added 5 M aq NaOH solution (7.58 ml, 37.9 mmol) and the mixture was heated at 60° C. for 16 h. The mixture was then cooled to RT, acidified to pH 1 with conc hydrochloric acid, and extracted 3 times with ethyl acetate. The combined organic phases were dried with Na2SO4. Evaporation in vacuo afforded the title compound (903 mg, 95%) as an off-white crystalline solid. MS (ISN): 275.1 M−H−.

Provenance & Evidence