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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2374256Generated: October 25, 2026

1-(4-(Trifluoromethyl)phenyl)piperazine → (2-Chloro-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone

https://huagongshe.com/reaction/2374256

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(4-(Trifluoromethyl)phenyl)piperazineHCID 121718—
Reactant2-Chloro-5-(methylsulphonyl)benzoic acidHCID 2329132—
Product(2-Chloro-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanoneHCID 59793689—

Reaction Steps

The title compound was prepared according to the procedure E described for example 9 from 1-(4-trifluromethylphenyl)piperazine (ABCR F07741NB, [30459-17-7] and 2-chloro-5-(methylsulfonyl)-benzoic acid (CAS: 89938-62-5); MS (m/e): 464.3 (M+NH4+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07462617B2
Source datasetuspto-grants-2008_12
ORD IDord-095f8ee249ae4cd8ab3217eb8050aa8a
Source noteuspto-grants-2008_12