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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2374259Generated: October 30, 2026

2-Fluoro-4-(piperazin-1-YL)benzonitrile → 2-Fluoro-4-[4-(5-methanesulfonyl-2-thiazol-2-yl-benzoyl)-piperazin-1-yl]-benzonitrile

https://huagongshe.com/reaction/2374259

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Fluoro-4-(piperazin-1-YL)benzonitrileHCID 18760045—
Reactant5-Methanesulfonyl-2-thiazol-2-yl-benzoic acidHCID 59853738—
Product2-Fluoro-4-[4-(5-methanesulfonyl-2-thiazol-2-yl-benzoyl)-piperazin-1-yl]-benzonitrileHCID 59853701—

Reaction Steps

The title compound was prepared according to the procedure E described for Example 9 from 2-Fluoro-4-piperazin-1-yl-benzonitrile [204192-45-0] and 5-Methanesulfonyl-2-thiazol-2-yl-benzoic acid (Example O). MS (ISP): 471.0 MH+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07462617B2
Source datasetuspto-grants-2008_12
ORD IDord-0324013b263a4cb19645beb51e8cb6b2
Source noteuspto-grants-2008_12