4-(Piperazin-1-yl)benzonitrile → 4-[4-(5-Methanesulfonyl-2-thiazol-2-yl-benzoyl)-piperazin-1-yl]-benzonitrile
Reaction equation
[N:1]1([C:7]2[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[CH3:15][S:16]([C:19]1[CH:20]=[CH:21][C:22]([C:28]2[S:29][CH:30]=[CH:31][N:32]=2)=[C:23]([CH:27]=1)[C:24](O)=[O:25])(=[O:18])=[O:17]>>[CH3:15][S:16]([C:19]1[CH:20]=[CH:21][C:22]([C:28]2[S:29][CH:30]=[CH:31][N:32]=2)=[C:23]([CH:27]=1)[C:24]([N:4]1[CH2:5][CH2:6][N:1]([C:7]2[CH:8]=[CH:9][C:10]([C:11]#[N:12])=[CH:13][CH:14]=2)[CH2:2][CH2:3]1)=[O:25])(=[O:17])=[O:18]Participants
3
Procedure
The title compound was prepared according to the procedure E described for Example 9 from 4-piperazin-1-yl-benzonitrile [68104-63-2] and 5-Methanesulfonyl-2-thiazol-2-yl-benzoic acid (Example O). MS (ISP): 453.5 MH+.
Sources & evidence
- ORD record
- ord-4177ec4f6a084b76bc920702d1285ca0
- Source dataset
- uspto-grants-2008_12
- Patent number
- US07462617B2
Reaction notes
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