1-(3-Fluoro-4-piperazin-1-ylphenyl)ethanone → 1-{3-Fluoro-4-[4-(5-methanesulfonyl-2-thiazol-2-yl-benzoyl)-piperazin-1-yl]-phenyl}-ethanone

HRID 2374262Notes

Reaction equation

HRID 2374262 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:14](=[O:16])[CH3:15])[CH:5]=[CH:6][C:7]=1[N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1.[CH3:17][S:18]([C:21]1[CH:22]=[CH:23][C:24]([C:30]2[S:31][CH:32]=[CH:33][N:34]=2)=[C:25]([CH:29]=1)[C:26](O)=[O:27])(=[O:20])=[O:19]>>[F:1][C:2]1[CH:3]=[C:4]([C:14](=[O:16])[CH3:15])[CH:5]=[CH:6][C:7]=1[N:8]1[CH2:13][CH2:12][N:11]([C:26](=[O:27])[C:25]2[CH:29]=[C:21]([S:18]([CH3:17])(=[O:20])=[O:19])[CH:22]=[CH:23][C:24]=2[C:30]2[S:31][CH:32]=[CH:33][N:34]=2)[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 6856101-(3-Fluoro-4-piperazin-1-ylphenyl)ethanoneHCID 598537385-Methanesulfonyl-2-thiazol-2-yl-benzoic acid

Product 1

HCID 598537421-{3-Fluoro-4-[4-(5-methanesulfonyl-2-thiazol-2-yl-benzoyl)-piperazin-1-yl]-phenyl}-ethanone

Procedure

The title compound was prepared according to the procedure E described for Example 9 from 1-(3-Fluoro-4-piperazin-1-yl-phenyl)-ethanone [189763-57-3] and 5-Methanesulfonyl-2-thiazol-2-yl-benzoic acid (Example O). MS (ISP): 488.5 MH+.

Sources & evidence

ORD record
ord-fc8ee2b4f7984aa9a5073e5f84044dd1
Source dataset
uspto-grants-2008_12
Patent number
US07462617B2

Reaction notes

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