1-[2-Fluoro-4-(methylsulfonyl)phenyl]piperazine → [4-(2-Fluoro-4-methanesulfonyl-phenyl)-piperazin-1-yl]-(5-methanesulfonyl-2-thiazol-2-yl-phenyl)-methanone

HRID 2374265Notes

Reaction equation

HRID 2374265 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([S:8]([CH3:11])(=[O:10])=[O:9])[CH:5]=[CH:4][C:3]=1[N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.[CH3:18][S:19]([C:22]1[CH:23]=[CH:24][C:25]([C:31]2[S:32][CH:33]=[CH:34][N:35]=2)=[C:26]([CH:30]=1)[C:27](O)=[O:28])(=[O:21])=[O:20]>>[F:1][C:2]1[CH:7]=[C:6]([S:8]([CH3:11])(=[O:10])=[O:9])[CH:5]=[CH:4][C:3]=1[N:12]1[CH2:17][CH2:16][N:15]([C:27]([C:26]2[CH:30]=[C:22]([S:19]([CH3:18])(=[O:21])=[O:20])[CH:23]=[CH:24][C:25]=2[C:31]2[S:32][CH:33]=[CH:34][N:35]=2)=[O:28])[CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 27827301-[2-Fluoro-4-(methylsulfonyl)phenyl]piperazineHCID 598537385-Methanesulfonyl-2-thiazol-2-yl-benzoic acid

Product 1

HCID 59853671[4-(2-Fluoro-4-methanesulfonyl-phenyl)-piperazin-1-yl]-(5-methanesulfonyl-2-thiazol-2-yl-phenyl)-methanone

Procedure

The title compound was prepared according to the procedure E described for Example 9 from 1-(2-Fluoro-4-methanesulfonyl-phenyl)-piperazine (Example Q) and 5-Methanesulfonyl-2-thiazol-2-yl-benzoic acid (Example O). MS (ISP): 524.3 MH+.

Sources & evidence

ORD record
ord-49869de4528f47cd9799f6eaf7eb575a
Source dataset
uspto-grants-2008_12
Patent number
US07462617B2

Reaction notes

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