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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2374269Generated: November 1, 2026

2-(Piperazin-1-yl)-4-(trifluoromethyl)pyrimidine → (4-Methanesulfonyl-biphenyl-2-yl)-[4-(4-trifluoromethyl-pyrimidin-2-yl)-piperazin-1-yl]-methanone

https://huagongshe.com/reaction/2374269

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Piperazin-1-yl)-4-(trifluoromethyl)pyrimidineHCID 2778334—
Reactant4-(methylsulfonyl)-Biphenyl-2-carboxylic acidHCID 57445254—
Product(4-Methanesulfonyl-biphenyl-2-yl)-[4-(4-trifluoromethyl-pyrimidin-2-yl)-piperazin-1-yl]-methanoneHCID 59853735—

Reaction Steps

The title compound was prepared according to the procedure E described for Example 9 from 2-Piperazin-1-yl-4-trifluoromethyl-pyrimidine [179756-91-3] and 4-Methanesulfonyl-biphenyl-2-carboxylic acid (Example V). MS (ISP): 491.1 MH+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07462617B2
Source datasetuspto-grants-2008_12
ORD IDord-a8850f75630b43bb9f8189687e47d222
Source noteuspto-grants-2008_12