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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2374270Generated: October 25, 2026

4-(methylsulfonyl)-Biphenyl-2-carboxylic acid → [4-(4-Cyclopropanesulfonyl-2-fluoro-phenyl)-piperazin-1-yl]-(4-methanesulfonyl-biphenyl-2-yl)-methanone

https://huagongshe.com/reaction/2374270

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(methylsulfonyl)-Biphenyl-2-carboxylic acidHCID 57445254—
Reactant1-(4-Cyclopropanesulfonyl-2-fluoro-phenyl)-piperazineHCID 59853665—
Product[4-(4-Cyclopropanesulfonyl-2-fluoro-phenyl)-piperazin-1-yl]-(4-methanesulfonyl-biphenyl-2-yl)-methanoneHCID 59853643—

Reaction Steps

The title compound was prepared according to the procedure E described for Example 9 from 1-(4-Cyclopropanesulfonyl-2-fluoro-phenyl)-piperazine (Example W) and 4-Methanesulfonyl-biphenyl-2-carboxylic acid (Example V). MS (ISP): 543.3 MH+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07462617B2
Source datasetuspto-grants-2008_12
ORD IDord-ff42736d68894285b75523a5380741a5
Source noteuspto-grants-2008_12