Ethyl 4-aminocyclohexanecarboxylate → 4-{4-[4-(2-Methanesulfonyl-ethoxy)-indazol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid ethyl ester

HRID 237428Notes

Reaction equation

HRID 237428 reaction equation
[CH2:1]([O:3][C:4]([CH:6]1[CH2:11][CH2:10][CH:9]([NH2:12])[CH2:8][CH2:7]1)=[O:5])[CH3:2].[CH3:13][S:14]([CH2:17][CH2:18][O:19][C:20]1[CH:28]=[CH:27][CH:26]=[C:25]2[C:21]=1[CH:22]=[N:23][N:24]2[C:29]1[CH:34]=[CH:33][N:32]=[C:31](S(CCC)(=O)=O)[N:30]=1)(=[O:16])=[O:15]>>[CH2:1]([O:3][C:4]([CH:6]1[CH2:11][CH2:10][CH:9]([NH:12][C:31]2[N:30]=[C:29]([N:24]3[C:25]4[C:21](=[C:20]([O:19][CH2:18][CH2:17][S:14]([CH3:13])(=[O:15])=[O:16])[CH:28]=[CH:27][CH:26]=4)[CH:22]=[N:23]3)[CH:34]=[CH:33][N:32]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 409963Ethyl 4-aminocyclohexanecarboxylateHCID 585421574-(2-methanesulfonyl-ethoxy)-1-[2-(propane-1-sulfonyl)-pyrimidin-4-yl]-1H-indazole

Product 1

HCID 585421724-{4-[4-(2-Methanesulfonyl-ethoxy)-indazol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid ethyl ester

Procedure

4-{4-[4-(2-Methanesulfonyl-ethoxy)-indazol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid ethyl ester was prepared by reaction of 4-amino-cyclohexanecarboxylic acid ethyl ester with 4-(2-methanesulfonyl-ethoxy)-1-[2-(propane-1-sulfonyl)-pyrimidin-4-yl]-1H-indazole following generally the procedure of Example 5.

Sources & evidence

ORD record
ord-b29759cd655348749faf06ccf7b1ef82
Source dataset
uspto-grants-2014_02
Patent number
US08642601B2

Reaction notes

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