HCID 11583787, compound → HCID 11306161, compound

Participants

Reaction Steps

(2-Cyclopent-1-enyl-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone (Example 74) is hydrogenated in MeOH in presence of 10% Pd/C under a hydrogen pressure of 50 bar at 50° C. for 18h. Filtration, evaporation of the solvent and purification of the residue by preparative HPLC on a C-18 column with a H2O/MeCN gradient provided (2-Cyclopentyl-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone in 94% yield as colourless foam (M+H+: 481.5.).

Provenance & Evidence