HCID 11271708, compound → HCID 59853755, compound

Participants

Reaction Steps

1-(4-{4-[2-(3,6-Dihydro-2H-pyran-4-yl)-5-methanesulfonyl-benzoyl]-piperazin-1-yl}-3-fluoro-phenyl)-ethanone (Example 72) is hydrogenated in EtOH in presence of Raney nickel under a hydrogen pressure of 100 bar at 100IC for 18 h. Filtration, evaporation of the solvent and purification of the residue by preparative HPLC on a C-18 column with a H2O/MeCN gradient provided [4-(4-Ethyl-2-fluoro-phenyl)-piperazin-1-yl]-[5-methanesulfonyl-2-(tetrahydro-pyran-4-yl)-phenyl]-methanone in 41% yield as colourless crystals (M+H+: 475.5.).

Provenance & Evidence