HCID 11752508, compound → HCID 69039211, compound

Participants

Reaction Steps

(2-Cyclohept-1-enyl-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone (Example 75) ) is hydrogenated in MeOH in presence of 10% Pd/C under a hydrogen pressure of 100 bar at 100° C. for 18 h. Filtration, evaporation of the solvent and purification of the residue by preparative HPLC on a C-18 column with a H2O/MeCN gradient provided (2-Cycloheptyl-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone in 73% yield as colourless gum (M+H+: 509.6.).

Provenance & Evidence