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Hydrazine → Pyrimidine-4-carbohydrazide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrazine | HCID 9321 | — |
| 反応物 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 反応物 | 4-Pyrimidinecarboxylic acid | HCID 169306 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Pyrimidine-4-carbohydrazide | HCID 468664 | — |
反応手順
To a solution of pyrimidine-4-carboxylic acid (1.0 g, 8.0 mmol) in THF (15 mL), N,N-Carbonyldiimidazole (1.4 g, 8.9 mmol) was added. After refluxing for 2 hours, hydrazine (0.8 g, 20 mmol) was added to the reaction mixture slowly with a syringe at 0° C. The reaction mixture was allowed to warm to room temperature slowly and then concentrated to yield the desired product as white solid. LCMS calculated for C5H7N4O (M+H): 139.1; found: 139.1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07462624B2 |
| 出典データセット | uspto-grants-2008_12 |
| ORD ID | ord-da186a477d874dcf971d3411831cfcc7 |
| 出典メモ | uspto-grants-2008_12 |