Hydrazinecarboxaldehyde → N-Pentyl-5-(1H-1,2,4-triazol-5-yl)-1H-imidazol-4-amine

HRID 2374330Notes

Reaction equation

HRID 2374330 reaction equation
[CH2:1]([NH:6][C:7]1[N:8]=[CH:9][NH:10][C:11]=1[C:12](SC)=[NH:13])[CH2:2][CH2:3][CH2:4][CH3:5].[CH:16]([NH:18][NH2:19])=O>C(O)C>[CH2:1]([NH:6][C:7]1[N:8]=[CH:9][NH:10][C:11]=1[C:12]1[NH:19][N:18]=[CH:16][N:13]=1)[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

4

Reactant 2

HCID 12229HydrazinecarboxaldehydeHCID 135984704methyl 4-(pentylamino)-1H-imidazole-5-carbimidothioate

Product 1

HCID 135984707N-Pentyl-5-(1H-1,2,4-triazol-5-yl)-1H-imidazol-4-amine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of methyl 4-(pentylamino)-1H-imidazole-5-carbimidothioate (0.53 g, 2.4 mmol) and formic hydrazide (0.21 g, 3.5 mmol) in ethanol (10 mL) was refluxed overnight. The reaction mixture was concentrated under reduced pressure to yield the desired product as a slightly green viscose oil. LCMS calculated for C10H17N6 (M+H): 221.2; found: 221.1.

Workup

  1. temperaturewas refluxed overnight
  2. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-367665b294f347d68cfd260bc14598b2
Source dataset
uspto-grants-2008_12
Patent number
US07462624B2

Reaction notes

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