4-Chloro-6-(3-chloropropoxy)-7-methoxyquinazoline → HCID 68544806, compound

HRID 2374427Notes

Reaction equation

HRID 2374427 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:17][CH3:18])=[C:9]([O:12][CH2:13][CH2:14][CH2:15][Cl:16])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:19][C:20]1[C:25]([Cl:26])=[CH:24][N:23]=[C:22]2[O:27][CH2:28][O:29][C:21]=12>>[Cl:16][CH2:15][CH2:14][CH2:13][O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[O:17][CH3:18])[N:5]=[CH:4][N:3]=[C:2]2[NH:19][C:20]1[C:25]([Cl:26])=[CH:24][N:23]=[C:22]2[O:27][CH2:28][O:29][C:21]=12

Participants

3

Reactant 2

HCID 507422644-Chloro-6-(3-chloropropoxy)-7-methoxyquinazolineHCID 685486516-chloro-2H-[1,3]dioxolo[4,5-b]pyridin-7-amine

Product 1

HCID 68544806HCID 68544806, compoundYield 58%

Procedure

Using an analogous procedure to that described in Example 1, 4-chloro-6-(3-chloropropoxy)-7-methoxyquinazoline was reacted with 4-amino-5-chloro-2,3-methylenedioxypyridine to give the title compound in 58% yield; NMR Spectrum: (CDCl3) 2.4 (m, 2H), 3.8 (t, 2H), 4.05 (s, 3H), 4.35 (t, 2H), 6.15 (s, 2H), 7.05 (s, 1H), 7.2 (s, 1H), 7.3 (s, 1H), 7.75 (s, 1H), 8.7 (s, 1H); Mass Spectrum: M+H+ 423 and 425.

Sources & evidence

ORD record
ord-6dae04e664af4332830aa30d4f2ebb9d
Source dataset
uspto-grants-2008_12
Patent number
US07462623B2

Reaction notes

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