Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 2-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)ethan-1-one | HCID 21984867 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | HCID 86609249 | HCID 86609249 | — |
Reaction Steps
7 ml of POCl3 are added dropwise to a solution of 6.6 ml of DMF in 4 ml of dichloroethane, cooled to −5° C., under nitrogen, and then the temperature is allowed to rise and 7 g of 2-(4-chlorophenyl)-1-(2,4-dichlorophenyl)ethanone are added. The reaction medium is heated at 50° C. for 16 hours and then the mixture is poured into 100 ml of ice-cold water. The medium is extracted with DCM and then the organic phase is washed with a saturated NaHCO3 solution, water, and then an NaCl solution. 1.45 g of the expected compound are obtained, which compound crystallizes from isopropyl ether, m.p.=128° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07462631B2 |
|---|
| Source dataset | uspto-grants-2008_12 |
|---|
| ORD ID | ord-85b984b3b2744261ba79a84cdc9d882a |
|---|
| Source note | uspto-grants-2008_12 |
|---|
