Methanol → 4-(Dimethylamino)-1,1-dimethoxybut-3-en-2-one

Participants

Reaction Steps

300 g (307 ml, 2.54 mol) of methylglyoxal dimethylacetal were stirred, at 110° C. for 4 hours (h), with 303 g (337 ml, 2.54 mol) of N,N-dimethylformamide dimethylacetal. The methanol which was formed during the reaction was removed continuously from the reaction solution by distillation. After having been cooled down, the solution was extracted with heptane and the solvents were evaporated. This resulted in 303 g of crude product 16 (yield 70%), which was reacted without any further purification.

Provenance & Evidence