2-Ethylbutyryl chloride → HCID 178445186, compound

HRID 2374507Notes

Reaction equation

HRID 2374507 reaction equation
[NH2:1][C:2]1[C:3]([C:7]2[NH:23][C:10]3=[CH:11][C:12]4[C:13]([CH3:22])([CH3:21])[C:14](=[O:20])[N:15]([CH2:18][CH3:19])[C:16]=4[CH:17]=[C:9]3[N:8]=2)=[N:4][NH:5][CH:6]=1.[CH2:24]([CH:26]([CH2:30][CH3:31])[C:27](Cl)=[O:28])[CH3:25]>>[CH2:24]([CH:26]([CH2:30][CH3:31])[C:27]([NH:1][C:2]1[C:3]([C:7]2[NH:23][C:10]3=[CH:11][C:12]4[C:13]([CH3:22])([CH3:21])[C:14](=[O:20])[N:15]([CH2:18][CH3:19])[C:16]=4[CH:17]=[C:9]3[N:8]=2)=[N:4][NH:5][CH:6]=1)=[O:28])[CH3:25]

Participants

3

Reactant 2

HCID 759542-Ethylbutyryl chlorideHCID 178462936HCID 178462936, compound

Product 1

HCID 178445186HCID 178445186, compound

Procedure

2-Ethyl-N-[3-(5-ethyl-7,7-dimethyl-6-oxo-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-1H-pyrazol-4-yl]-butyramide was prepared using 2-(4-amino-1H-pyrazol-3-yl)-5-ethyl-7,7-dimethyl-5,7-dihydro-1H-imidazo[4,5-f]indol-6-one (250 mg, 0.81 mmol) and 2-ethylbutyryl chloride (121 μl, 0.87 mmol). The title compound was obtained as yellow powder (230 mg, 70%).

Workup

  1. custom2-Ethyl-N-[3-(5-ethyl-7,7-dimethyl-6-oxo-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-1H-pyrazol-4-yl]-butyramide was prepared

Sources & evidence

ORD record
ord-3994422df3534e13bec22b484cdde1cc
Source dataset
uspto-grants-2008_12
Patent number
US07462639B2

Reaction notes

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