3-Chloro-2,2-dimethylpropanoyl chloride → HCID 178462911, compound

HRID 2374509Notes

Reaction equation

HRID 2374509 reaction equation
[NH2:1][C:2]1[C:3]([C:7]2[NH:23][C:10]3=[CH:11][C:12]4[C:13]([CH3:22])([CH3:21])[C:14](=[O:20])[N:15]([CH2:18][CH3:19])[C:16]=4[CH:17]=[C:9]3[N:8]=2)=[N:4][NH:5][CH:6]=1.[Cl:24][CH2:25][C:26]([CH3:31])([CH3:30])[C:27](Cl)=[O:28]>>[Cl:24][CH2:25][C:26]([CH3:31])([CH3:30])[C:27]([NH:1][C:2]1[C:3]([C:7]2[NH:23][C:10]3=[CH:11][C:12]4[C:13]([CH3:22])([CH3:21])[C:14](=[O:20])[N:15]([CH2:18][CH3:19])[C:16]=4[CH:17]=[C:9]3[N:8]=2)=[N:4][NH:5][CH:6]=1)=[O:28]

Participants

3

Reactant 2

HCID 613453-Chloro-2,2-dimethylpropanoyl chlorideHCID 178462936HCID 178462936, compound

Product 1

HCID 178462911HCID 178462911, compound

Procedure

3-Chloro-N-[3-(5-ethyl-7,7-dimethyl-6-oxo-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-1H-pyrazol-4-yl]-2,2-dimethyl-propionamide was prepared using 2-(4-amino-1H-pyrazol-3-yl)-5-ethyl-7,7-dimethyl-5,7-dihydro-1H-imidazo[4,5-f]indol-6-one (250 mg, 0.81 mmol) and 3-chloropivaloyl chloride (115 μl, 0.89 mmol). The title compound was obtained as yellow powder (239 mg, 69%).

Workup

  1. custom3-Chloro-N-[3-(5-ethyl-7,7-dimethyl-6-oxo-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-1H-pyrazol-4-yl]-2,2-dimethyl-propionamide was prepared

Sources & evidence

ORD record
ord-21961ccfdecd4ad390861b60730152f0
Source dataset
uspto-grants-2008_12
Patent number
US07462639B2

Reaction notes

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