Quinoxaline-2-carbonyl chloride → HCID 178462902, compound

HRID 2374514Notes

Reaction equation

HRID 2374514 reaction equation
[NH2:1][C:2]1[C:3]([C:7]2[NH:23][C:10]3=[CH:11][C:12]4[C:13]([CH3:22])([CH3:21])[C:14](=[O:20])[N:15]([CH2:18][CH3:19])[C:16]=4[CH:17]=[C:9]3[N:8]=2)=[N:4][NH:5][CH:6]=1.[N:24]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[N:27]=[CH:26][C:25]=1[C:34](Cl)=[O:35]>>[CH2:18]([N:15]1[C:16]2[CH:17]=[C:9]3[N:8]=[C:7]([C:3]4[C:2]([NH:1][C:34]([C:25]5[CH:26]=[N:27][C:28]6[C:33](=[CH:32][CH:31]=[CH:30][CH:29]=6)[N:24]=5)=[O:35])=[CH:6][NH:5][N:4]=4)[NH:23][C:10]3=[CH:11][C:12]=2[C:13]([CH3:22])([CH3:21])[C:14]1=[O:20])[CH3:19]

Participants

3

Reactant 2

HCID 2734681Quinoxaline-2-carbonyl chlorideHCID 178462936HCID 178462936, compound

Product 1

HCID 178462902HCID 178462902, compound

Procedure

Quinoxaline-2-carboxylic acid[3-(5-ethyl-7,7-dimethyl-6-oxo-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-1H-pyrazol-4-yl]-amide was prepared using 2-(4-amino-1H-pyrazol-3-yl)-5-ethyl-7,7-dimethyl-5,7-dihydro-1H-imidazo[4,5-f]indol-6-one (250 mg, 0.81 mmol) and 2-quinoxalinecarbonyl chloride (170 mg, 0.89 mmol). The title compound was obtained as yellow powder (158 mg, 42%).

Workup

  1. customQuinoxaline-2-carboxylic acid[3-(5-ethyl-7,7-dimethyl-6-oxo-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-1H-pyrazol-4-yl]-amide was prepared

Sources & evidence

ORD record
ord-f6e9badd53c24d09a08ab18ac1e21691
Source dataset
uspto-grants-2008_12
Patent number
US07462639B2

Reaction notes

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