trans-2-Phenyl-1-cyclopropanecarbonyl chloride → HCID 178462879, compound

HRID 2374517Notes

Reaction equation

HRID 2374517 reaction equation
[NH2:1][C:2]1[C:3]([C:7]2[NH:23][C:10]3=[CH:11][C:12]4[C:13]([CH3:22])([CH3:21])[C:14](=[O:20])[N:15]([CH2:18][CH3:19])[C:16]=4[CH:17]=[C:9]3[N:8]=2)=[N:4][NH:5][CH:6]=1.[C:24]1([C@@H:30]2[CH2:32][C@H:31]2[C:33](Cl)=[O:34])[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[CH2:18]([N:15]1[C:16]2[CH:17]=[C:9]3[N:8]=[C:7]([C:3]4[C:2]([NH:1][C:33]([CH:31]5[CH2:32][CH:30]5[C:24]5[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=5)=[O:34])=[CH:6][NH:5][N:4]=4)[NH:23][C:10]3=[CH:11][C:12]=2[C:13]([CH3:22])([CH3:21])[C:14]1=[O:20])[CH3:19]

Participants

3

Reactant 2

HCID 13656trans-2-Phenyl-1-cyclopropanecarbonyl chlorideHCID 178462936HCID 178462936, compound

Product 1

HCID 178462879HCID 178462879, compound

Procedure

2-Phenyl-cyclopropanecarboxylic acid[3-(5-ethyl-7,7-dimethyl-6-oxo-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-1H-pyrazol-4-yl]-amide was prepared using 2-(4-amino-1H-pyrazol-3-yl)-5-ethyl-7,7-dimethyl-5,7-dihydro-1H-imidazo[4,5-f]indol-6-one (250 mg, 0.81 mmol) and trans-2-phenyl cyclopropan-1-carbonyl chloride (137 μl, 0.89 mmol). The title compound was obtained as yellow powder (216 mg, 59%).

Workup

  1. custom2-Phenyl-cyclopropanecarboxylic acid[3-(5-ethyl-7,7-dimethyl-6-oxo-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-1H-pyrazol-4-yl]-amide was prepared

Sources & evidence

ORD record
ord-d0982974af174c3a84e806497bb722fc
Source dataset
uspto-grants-2008_12
Patent number
US07462639B2

Reaction notes

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