DL-2-Phenoxypropionic acid → HCID 178462916, compound

HRID 2374531Notes

Reaction equation

HRID 2374531 reaction equation
[NH2:1][C:2]1[C:3]([C:7]2[NH:23][C:10]3=[CH:11][C:12]4[C:13]([CH3:22])([CH3:21])[C:14](=[O:20])[N:15]([CH2:18][CH3:19])[C:16]=4[CH:17]=[C:9]3[N:8]=2)=[N:4][NH:5][CH:6]=1.[O:24]([CH:31]([CH3:35])[C:32](O)=[O:33])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[CH2:18]([N:15]1[C:16]2[CH:17]=[C:9]3[N:8]=[C:7]([C:3]4[C:2]([NH:1][C:32](=[O:33])[CH:31]([O:24][C:25]5[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=5)[CH3:35])=[CH:6][NH:5][N:4]=4)[NH:23][C:10]3=[CH:11][C:12]=2[C:13]([CH3:22])([CH3:21])[C:14]1=[O:20])[CH3:19]

Participants

3

Reactant 2

HCID 13658DL-2-Phenoxypropionic acidHCID 178462936HCID 178462936, compound

Product 1

HCID 178462916HCID 178462916, compound

Procedure

N-[3-(5-Ethyl-7,7-dimethyl-6-oxo-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-1H-pyrazol-4-yl]-2-phenoxy-propionamide was prepared using 2-(4-amino-1H-pyrazol-3-yl)-5-ethyl-7,7-dimethyl-5,7-dihydro-1H-imidazo[4,5-f]indol-6-one (250 mg, 0.81 mmol) and 2-phenoxypropionic acid (147 mg, 0.89 mmol). The title compound was obtained as white powder (15 mg, 4%).

Workup

  1. customN-[3-(5-Ethyl-7,7-dimethyl-6-oxo-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-1H-pyrazol-4-yl]-2-phenoxy-propionamide was prepared

Sources & evidence

ORD record
ord-53282c7e12b84a36b9a0551a4c21d4fd
Source dataset
uspto-grants-2008_12
Patent number
US07462639B2

Reaction notes

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