3,5-diethoxybenzoic acid → HCID 178467024, compound

HRID 2374537Notes

Reaction equation

[NH2:1][C:2]1[C:3]([C:7]2[NH:23][C:10]3=[CH:11][C:12]4[C:13]([CH3:22])([CH3:21])[C:14](=[O:20])[N:15]([CH2:18][CH3:19])[C:16]=4[CH:17]=[C:9]3[N:8]=2)=[N:4][NH:5][CH:6]=1.[CH2:24]([O:26][C:27]1[CH:28]=[C:29]([CH:33]=[C:34]([O:36][CH2:37][CH3:38])[CH:35]=1)[C:30](O)=[O:31])[CH3:25]>>[CH2:37]([O:36][C:34]1[CH:33]=[C:29]([CH:28]=[C:27]([O:26][CH2:24][CH3:25])[CH:35]=1)[C:30]([NH:1][C:2]1[C:3]([C:7]2[NH:23][C:10]3=[CH:11][C:12]4[C:13]([CH3:22])([CH3:21])[C:14](=[O:20])[N:15]([CH2:18][CH3:19])[C:16]=4[CH:17]=[C:9]3[N:8]=2)=[N:4][NH:5][CH:6]=1)=[O:31])[CH3:38]

Participants

Reactant 2

HCID 7211363,5-diethoxybenzoic acid

HCID 178462936HCID 178462936, compound

Product 1

HCID 178467024HCID 178467024, compound

Procedure

3,5-Diethoxy-N-[3-(5-ethyl-7,7-dimethyl-6-oxo-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-1H-pyrazol-4-yl]-benzamide was prepared using 2-(4-amino-1H-pyrazol-3-yl)-5-ethyl-7,7-dimethyl-5,7-dihydro-1H-imidazo[4,5-f]indol-6-one (250 mg, 0.81 mmol) and 3,5-diethoxybenzoic acid (186 mg, 0.89 mmol). The title compound was obtained as brown powder (99 mg, 24%).

Workup

custom3,5-Diethoxy-N-[3-(5-ethyl-7,7-dimethyl-6-oxo-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-1H-pyrazol-4-yl]-benzamide was prepared

Sources & evidence

ORD record: ord-384ce4a5034d448a9b941b559f464a1e
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07462639B2

Reaction notes

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