1-Methylcyclopropanecarboxylic acid → HCID 178456523, compound

HRID 2374539Notes

Reaction equation

HRID 2374539 reaction equation
[NH2:1][C:2]1[C:3]([C:7]2[NH:8][C:9]3[C:10]([N:24]=2)=[CH:11][C:12]2[C:13]([CH3:23])([CH3:22])[C:14](=[O:21])[N:15]([CH:18]([CH3:20])[CH3:19])[C:16]=2[CH:17]=3)=[N:4][NH:5][CH:6]=1.[CH3:25][C:26]1([C:29](O)=[O:30])[CH2:28][CH2:27]1>>[CH:18]([N:15]1[C:16]2[CH:17]=[C:9]3[NH:8][C:7]([C:3]4[C:2]([NH:1][C:29]([C:26]5([CH3:25])[CH2:28][CH2:27]5)=[O:30])=[CH:6][NH:5][N:4]=4)=[N:24][C:10]3=[CH:11][C:12]=2[C:13]([CH3:22])([CH3:23])[C:14]1=[O:21])([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 813261-Methylcyclopropanecarboxylic acidHCID 178456525HCID 178456525, compound

Product 1

HCID 178456523HCID 178456523, compoundYield 56%

Procedure

Methyl-cyclopropanecarboxylic acid[3-(5-isopropyl-7,7-dimethyl-6-oxo-3,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-1H-pyrazol-4-yl]-amide was prepared using 2-(4-amino-1H-pyrazol-3-yl)-5-isopropyl-7,7-dimethyl-5,7-dihydro-3H-imidazo[4,5-f]indol-6-one (300 mg. 0.925 mmol) and 1-methyl-cyclopropanecarboxylic acid (101.8 mg, 1.017 mmol). 210 mg (56%) of the title compound were obtained.

Workup

  1. customMethyl-cyclopropanecarboxylic acid[3-(5-isopropyl-7,7-dimethyl-6-oxo-3,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-1H-pyrazol-4-yl]-amide was prepared

Sources & evidence

ORD record
ord-34c28c76b5ce44c0a5e82ce4cc80702c
Source dataset
uspto-grants-2008_12
Patent number
US07462639B2

Reaction notes

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