1-Methylcyclopropanecarboxylic acid → HCID 178436692, compound

HRID 2374540Notes

Reaction equation

HRID 2374540 reaction equation
[NH2:1][C:2]1[C:3]([C:7]2[NH:26][C:10]3=[CH:11][C:12]4[C:13]([CH2:24][CH3:25])([CH2:22][CH3:23])[C:14](=[O:21])[N:15]([CH:18]([CH3:20])[CH3:19])[C:16]=4[CH:17]=[C:9]3[N:8]=2)=[N:4][NH:5][CH:6]=1.[CH3:27][C:28]1([C:31](O)=[O:32])[CH2:30][CH2:29]1>>[CH2:24]([C:13]1([CH2:22][CH3:23])[C:12]2[CH:11]=[C:10]3[NH:26][C:7]([C:3]4[C:2]([NH:1][C:31]([C:28]5([CH3:27])[CH2:30][CH2:29]5)=[O:32])=[CH:6][NH:5][N:4]=4)=[N:8][C:9]3=[CH:17][C:16]=2[N:15]([CH:18]([CH3:20])[CH3:19])[C:14]1=[O:21])[CH3:25]

Participants

3

Reactant 2

HCID 813261-Methylcyclopropanecarboxylic acidHCID 178436694HCID 178436694, compound

Product 1

HCID 178436692HCID 178436692, compound

Procedure

Methyl-cyclopropanecarboxylic acid[3-(7,7-diethyl-5-isopropyl-6-oxo-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-1H-pyrazol-4-yl]-amide was prepared using 2-(4-Amino-1H-pyrazol-3-yl)-7,7-diethyl-5-isopropyl-5,7-dihydro-1H-imidazo[4,5-f]indol-6-one (150 mg, 0.43 mmol) and 1-methyl-cyclopropane-carboxylic acid (51 mg, 0.43 mmol). 17 mg (9%) %) of the title compound were obtained.

Workup

  1. customMethyl-cyclopropanecarboxylic acid[3-(7,7-diethyl-5-isopropyl-6-oxo-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-1H-pyrazol-4-yl]-amide was prepared

Sources & evidence

ORD record
ord-5c27fdfcc00941178a4778f577afebe8
Source dataset
uspto-grants-2008_12
Patent number
US07462639B2

Reaction notes

Loading…