4-Methyl-1-piperazinecarbonyl chloride → HCID 178462922, compound

HRID 2374544Notes

Reaction equation

HRID 2374544 reaction equation
[NH2:1][C:2]1[C:3]([C:7]2[NH:23][C:10]3=[CH:11][C:12]4[C:13]([CH3:22])([CH3:21])[C:14](=[O:20])[N:15]([CH2:18][CH3:19])[C:16]=4[CH:17]=[C:9]3[N:8]=2)=[N:4][NH:5][CH:6]=1.[CH3:24][N:25]1[CH2:30][CH2:29][N:28]([C:31](Cl)=[O:32])[CH2:27][CH2:26]1>>[CH2:18]([N:15]1[C:16]2[CH:17]=[C:9]3[N:8]=[C:7]([C:3]4[C:2]([NH:1][C:31]([N:28]5[CH2:29][CH2:30][N:25]([CH3:24])[CH2:26][CH2:27]5)=[O:32])=[CH:6][NH:5][N:4]=4)[NH:23][C:10]3=[CH:11][C:12]=2[C:13]([CH3:22])([CH3:21])[C:14]1=[O:20])[CH3:19]

Participants

3

Reactant 2

HCID 30169354-Methyl-1-piperazinecarbonyl chlorideHCID 178462936HCID 178462936, compound

Product 1

HCID 178462922HCID 178462922, compound

Procedure

4-Methyl-piperazine-1-carboxylic acid[3-(5-ethyl-7,7-dimethyl-6-oxo-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-1H-pyrazol-4-yl]-amide was prepared using 2-(4-amino-1H-pyrazol-3-yl)-5-ethyl-7,7-dimethyl-5,7-dihydro-1H-imidazo[4,5-f]indol-6-one (150 mg, 0.48 mmol) and 4-methyl-1-piperazinecarbonyl chloride. The title compound was obtained as light yellow powder (50 mg).

Workup

  1. custom4-Methyl-piperazine-1-carboxylic acid[3-(5-ethyl-7,7-dimethyl-6-oxo-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-1H-pyrazol-4-yl]-amide was prepared

Sources & evidence

ORD record
ord-0061870836d04003a2546f2250cccffc
Source dataset
uspto-grants-2008_12
Patent number
US07462639B2

Reaction notes

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