2,2-Dimethylpropyl carbonochloridate → HCID 178462931, compound

HRID 2374552Notes

Reaction equation

HRID 2374552 reaction equation
[NH2:1][C:2]1[C:3]([C:7]2[NH:23][C:10]3=[CH:11][C:12]4[C:13]([CH3:22])([CH3:21])[C:14](=[O:20])[N:15]([CH2:18][CH3:19])[C:16]=4[CH:17]=[C:9]3[N:8]=2)=[N:4][NH:5][CH:6]=1.Cl[C:25]([O:27][CH2:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:26]>>[CH3:30][C:29]([CH3:32])([CH3:31])[CH2:28][O:27][C:25](=[O:26])[NH:1][C:2]1[C:3]([C:7]2[NH:23][C:10]3=[CH:11][C:12]4[C:13]([CH3:22])([CH3:21])[C:14](=[O:20])[N:15]([CH2:18][CH3:19])[C:16]=4[CH:17]=[C:9]3[N:8]=2)=[N:4][NH:5][CH:6]=1

Participants

3

Reactant 2

HCID 33521852,2-Dimethylpropyl carbonochloridateHCID 178462936HCID 178462936, compound

Product 1

HCID 178462931HCID 178462931, compound

Procedure

[3-(5-Ethyl-7,7-dimethyl-6-oxo-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-1H-pyrazol-4-yl]-carbamic acid 2,2-dimethyl-propyl ester was prepared using 2-(4-amino-1H-pyrazol-3-yl)-5-ethyl-7,7-dimethyl-5,7-dihydro-1H-imidazo[4,5-f]indol-6-one (250 mg, 0.81 mmol) and 2,2-dimethylpropyl chloroformate (131 μl, 0.89 mmol). The title compound was obtained as yellow powder (245 mg, 71%).

Workup

  1. custom[3-(5-Ethyl-7,7-dimethyl-6-oxo-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-1H-pyrazol-4-yl]-carbamic acid 2,2-dimethyl-propyl ester was prepared

Sources & evidence

ORD record
ord-d42afaa576204d91b5ca1c5a8ec8b593
Source dataset
uspto-grants-2008_12
Patent number
US07462639B2

Reaction notes

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