Methanesulfonyl chloride → HCID 178462876, compound

HRID 2374564Notes

Reaction equation

HRID 2374564 reaction equation
[NH2:1][C:2]1[C:3]([C:7]2[NH:23][C:10]3=[CH:11][C:12]4[C:13]([CH3:22])([CH3:21])[C:14](=[O:20])[N:15]([CH2:18][CH3:19])[C:16]=4[CH:17]=[C:9]3[N:8]=2)=[N:4][NH:5][CH:6]=1.[CH3:24][S:25](Cl)(=[O:27])=[O:26]>>[CH2:18]([N:15]1[C:16]2[CH:17]=[C:9]3[NH:8][C:7]([C:3]4[C:2]([NH:1][S:25]([CH3:24])(=[O:27])=[O:26])=[CH:6][NH:5][N:4]=4)=[N:23][C:10]3=[CH:11][C:12]=2[C:13]([CH3:22])([CH3:21])[C:14]1=[O:20])[CH3:19]

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 178462936HCID 178462936, compound

Product 1

HCID 178462876HCID 178462876, compound

Procedure

N-[3-(5-Ethyl-7,7-dimethyl-6-oxo-3,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-1H-pyrazol-4-yl]-methanesulfonamide was prepared using 2-(4-Amino-1H-pyrazol-3-yl)-5-ethyl-7,7-dimethyl-5,7-dihydro-1H-imidazo[4,5-f]indol-6-one (100 mg, 0.32 mmol) and Methansulfonylchloride (30 μl, 0.39 mmol). The title compound was obtained as off-white powder (30 mg, 24%).

Workup

  1. customN-[3-(5-Ethyl-7,7-dimethyl-6-oxo-3,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-1H-pyrazol-4-yl]-methanesulfonamide was prepared

Sources & evidence

ORD record
ord-d021f37efabd49efbf2f17f38b9bb0be
Source dataset
uspto-grants-2008_12
Patent number
US07462639B2

Reaction notes

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