HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 237460Generated: November 2, 2026
Cesium carbonate → 2-(4-Bromo-3,5-dimethylphenoxy)acetonitrile
https://huagongshe.com/reaction/237460
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Bromoacetonitrile | HCID 11534 | — |
| Reactant | 4-Bromo-3,5-dimethylphenol | HCID 81970 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(4-Bromo-3,5-dimethylphenoxy)acetonitrile | HCID 22688454 | — |
Reaction Steps
To a solution of 4-bromo-3,5-dimethylphenol (500 mg) and Cs2CO3 (1.3 g) in N,N-dimethylformamide (5 mL) is added 2-bromoacetonitrile (290 μL) and the mixture is stirred for 2 hours at 35° C. The mixture is poured on water and stirred for 15 minutes. The precipitate is folitered off and dried to give the title compound. Yield: 535 mg; Mass spectrum (EI): m/z=239 [M]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08642585B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-3280135496314942a93d4b7ce9275b50 |
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| Source note | uspto-grants-2014_02 |
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