2-(4-Bromo-3,5-dimethylphenoxy)acetonitrile → Methyl 2-((S)-6-((R)-4-(4-(cyanomethoxy)-2,6-dimethylphenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

Participants

Reaction Steps

The title compound is prepared from methyl 2-((S)-6-((R)-7-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate and 2-(4-bromo-3,5-dimethylphenoxy)acetonitrile following a procedure analogous to that described in Step 5 of Intermediate 1. LC (method 8): tR=0.71 min; Mass spectrum (ESI+): m/z=502 [M+H]+.

Provenance & Evidence