Hydrogen chloride-ethyl acetate → HCID 21886885, compound

HRID 2374617Notes

Reaction equation

HRID 2374617 reaction equation
C(OCC)(=O)C.[ClH:7].[O:8]=[C:9]([C:30]1[CH:31]=[C:32]2[C:37]3=[C:38]([CH2:40][CH2:41][N:36]3[C:35](=[O:42])[CH2:34][CH2:33]2)[CH:39]=1)[CH2:10][CH2:11][CH2:12][CH2:13][N:14]([CH2:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)C(=O)OC(C)(C)C>C(O)C>[ClH:7].[C:24]1([CH2:23][CH2:22][NH:14][CH2:13][CH2:12][CH2:11][CH2:10][C:9]([C:30]2[CH:31]=[C:32]3[C:37]4=[C:38]([CH2:40][CH2:41][N:36]4[C:35](=[O:42])[CH2:34][CH2:33]3)[CH:39]=2)=[O:8])[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 21886975HCID 21886975, compound

Product 1

HCID 21886885HCID 21886885, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 4N hydrogen chloride-ethyl acetate solution was added to a solution of tert-butyl 5-oxo-5-(4-oxo-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-8-yl)pentyl(2-phenylethyl)carbamate (3.00 g) obtained in Reference Example 19 in ethanol (5 ml), and the mixture was stirred at room temperature for 1 hour. The solvent was evaporated under reduced pressure, and the resulting residue was crystallized from ethanol-ethyl acetate to give the title compound as colorless crystals (1.98 g) having a melting point of 166 to 168° C.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe resulting residue was crystallized from ethanol-ethyl acetate

Sources & evidence

ORD record
ord-a43941c0fe8840e9a2a12ad09679ada1
Source dataset
uspto-grants-2008_12
Patent number
US07462628B2

Reaction notes

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