1,3-dimethyl-1,3-dihydro-2H-benzimidazol-2-one → HCID 21887034, compound

HRID 2374629Notes

Reaction equation

HRID 2374629 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]([CH3:11])[C:3]1=[O:12].[Cl:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[CH2:20][CH2:21][N:22]([CH3:31])[CH:23]([CH3:30])[CH2:24][CH2:25][CH2:26][C:27](O)=[O:28]>>[ClH:13].[CH3:11][N:4]1[C:5]2[CH:10]=[CH:9][C:8]([C:27](=[O:28])[CH2:26][CH2:25][CH2:24][CH:23]([N:22]([CH2:21][CH2:20][C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[Cl:13])[CH3:31])[CH3:30])=[CH:7][C:6]=2[N:2]([CH3:1])[C:3]1=[O:12]

Participants

3

Reactant 2

HCID 2315531,3-dimethyl-1,3-dihydro-2H-benzimidazol-2-oneHCID 21887510HCID 21887510, compound

Product 1

HCID 21887034HCID 21887034, compoundYield 112.2%

Procedure

Using 484 mg (3 mmol) of 1,3-dimethyl-1,3-dihydro-2H-benzimidazol-2-one and 850 mg (3.3 mmol) of (±)-5-[[2-(2-chlorophenyl)ethyl](methyl)amino]hexanoic acid obtained in Reference Example 202 according to the same method as that of Example, a free base compound of the title compound (860 mg) was obtained as a pale yellow oil.

Workup

  1. customobtained in Reference Example 202 according to the same method as that of Example

Sources & evidence

ORD record
ord-c0c07b19159e440299133dc733bc9535
Source dataset
uspto-grants-2008_12
Patent number
US07462628B2

Reaction notes

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