HRID2374632

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID311

Citric acid

C6H8O7

结构：Cl.O=C(CCCCNCCc1ccccc1Cl)c1cc2c3c(c1)CC(=O)N3CCC2

HCID21887313

未命名化合物

PRODUCTS

生成物

结构：O=C(CCCCNCCc1ccccc1Cl)c1cc2c3c(c1)CC(=O)N3CCC2.O=C(O)CC(O)(CC(=O)O)C(=O)O

HCID21887943

未命名化合物

PROCEDURE

实验过程

Using 8-(5-{[2-(2-chlorophenyl)ethyl]amino}pentanoyl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-one hydrochloride (205 mg, 0.5 mmol) obtained in Example 39 and citric acid (96 mg, 0.5 mmol) according to the same method as that of Example 360, the title compound was obtained as colorless crystals (278 mg) having a melting point of 100 to 102° C. (dec).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e6cd20a74b3d4399819cb902cd66efbc
来源数据集: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07462628B2
来源说明: uspto-grants-2008_12

反应 SMILES

Cl.[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([C:18]1[CH:19]=[C:20]2[C:25]3=[C:26]([CH2:28][C:29](=[O:30])[N:24]3[CH2:23][CH2:22][CH2:21]2)[CH:27]=1)=[O:17].[C:31]([OH:43])(=[O:42])[CH2:32][C:33]([CH2:38][C:39]([OH:41])=[O:40])([C:35]([OH:37])=[O:36])[OH:34]>>[C:31]([OH:43])(=[O:42])[CH2:32][C:33]([CH2:38][C:39]([OH:41])=[O:40])([C:35]([OH:37])=[O:36])[OH:34].[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([C:18]1[CH:19]=[C:20]2[C:25]3=[C:26]([CH2:28][C:29](=[O:30])[N:24]3[CH2:23][CH2:22][CH2:21]2)[CH:27]=1)=[O:17]