Oxalic Acid → HCID 21887847, compound

HRID 2374633Notes

Reaction equation

Cl.[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([C:18]1[CH:19]=[C:20]2[C:25]3=[C:26]([CH2:28][C:29](=[O:30])[N:24]3[CH2:23][CH2:22][CH2:21]2)[CH:27]=1)=[O:17].[C:31]([OH:36])(=[O:35])[C:32]([OH:34])=[O:33]>>[C:31]([OH:36])(=[O:35])[C:32]([OH:34])=[O:33].[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([C:18]1[CH:19]=[C:20]2[C:25]3=[C:26]([CH2:28][C:29](=[O:30])[N:24]3[CH2:23][CH2:22][CH2:21]2)[CH:27]=1)=[O:17]

Participants

Reactant 2

HCID 971Oxalic Acid

HCID 21887313HCID 21887313, compound

Product 1

HCID 21887847HCID 21887847, compound

Procedure

Using 8-(5-{[2-(2-chlorophenyl)ethyl]amino}pentanoyl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-one hydrochloride (205 mg, 0.5 mmol) obtained in Example 39 and oxalic acid (45 mg, 0.5 mmol) according to the same method as that of Example 360, the title compound was obtained as colorless crystals (221 mg) having a melting point of 161 to 163° C. (dec).

Sources & evidence

ORD record: ord-ce71018589e3460e8bfe29e25dec1683
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07462628B2

Reaction notes

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