HCID 49797468, compound → HCID 9820646, compound

HRID 2374648Notes

Reaction equation

HRID 2374648 reaction equation
C1C=CN=CC=1.[CH:7]1[C:8]2[C:21]3=[CH:22][C@H:23]([OH:31])[C@H:24]4[O:29][P:27]([OH:30])(=[O:28])[O:26][C@H:25]4[C@@H:20]3[NH:19][C:17](=[O:18])[C:9]=2[C:10]([OH:16])=[C:11]2[O:15][CH2:14][O:13][C:12]=12>O>[CH:7]1[C:8]2[C:21]3=[CH:22][C@H:23]([OH:31])[C@H:24]4[O:29][P:27]([OH:30])(=[O:28])[O:26][C@H:25]4[C@@H:20]3[NH:19][C:17](=[O:18])[C:9]=2[C:10]([OH:16])=[C:11]2[O:15][CH2:14][O:13][C:12]=12

Participants

3

Reactant 1

HCID 49797468HCID 49797468, compound

Product 1

HCID 9820646HCID 9820646, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Pyridinium narcistatin (3a, 50 mg) was dissolved in water (35 ml) and the solution passed through a column (1×20 cm) of Dowex 50W-X2 bearing the respective cation. The u.v. active fractions were combined and freeze dried to give the corresponding narcistatin salt as a colorless solid unless otherwise recorded. The solubility of each in water (mg/ml) now follows: 3c, >50 mg; 3d, 60 mg; 3e, 11 mg; 3f, <13 mg.

Workup

  1. customfreeze dried

Sources & evidence

ORD record
ord-5262067d364b4a61b652b51e3047c88f
Source dataset
uspto-grants-2008_12
Patent number
US07462609B2

Reaction notes

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