참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 4-Formylphenylboronic Acid | HCID 591073 | — |
| 반응물 | 2-(4-bromophenyl)-1H-benzimidazole-4-carboxamide | HCID 44542365 | — |
| 촉매 | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 2-(4'-formylbipheny-4-yl)-1H-benzimidazole-4-carboxamide | HCID 87500516 | — |
반응 단계
A solution of EXAMPLE 3A (1.18 g, 3.8 mmol) and 4-formylphenylboronic acid (0.57 g, 3.8 mmol) in dioxane (15 mL) was treated with [1,1′-bis(diphenylphosphino)ferrocene]dichloro palladium (0.32 g, 0.4 mmol) and sodium carbonate (1.8 g, 17 mmol). The mixture was heated at 95° C. for 24 hours, then cooled and filtered. The filtrate was concentrated to provide the crude product, which was used without further purification. MS (ESI) m/e 342 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07462724B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_12 |
|---|
| ORD ID | ord-12604c09c6eb42efa971923310e6cf86 |
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| 출처 메모 | uspto-grants-2008_12 |
|---|
