HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2374677Generated: October 25, 2026
Acetic Acid → 2-(5-acetylthiophen-2-yl)-1H-benzimidazole-4-carboxamide
https://huagongshe.com/reaction/2374677
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 5-Acetylthiophene-2-carboxylic acid (2-amino-3-carbamoylphenyl)amide | HCID 67353795 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(5-acetylthiophen-2-yl)-1H-benzimidazole-4-carboxamide | HCID 67352032 | 95.1% |
Reaction Steps
To a solution of EXAMPLE 6A (1.70 g) in hot N,N-dimethylformamide (60 mL) was added acetic acid (50 mL) and the solution heated at 125° C. for 3 hours. After cooling, the resulting yellow solid was collected by filtration, washed with methanol and dried to give the title compound (1.52 g, 95%). MS (APCI): 286 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07462724B2 |
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| Source dataset | uspto-grants-2008_12 |
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| ORD ID | ord-9d230c6fccc441b4afd3f8ab118776b8 |
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| Source note | uspto-grants-2008_12 |
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