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Sodium Hydroxide → 6-Pyridin-2-yl-3-oxo-2,3,4,5-tetrahydropyridazine-4-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Ethyl 3-oxo-6-(pyridin-2-yl)-2,3-dihydropyridazine-4-carboxylate | HCID 20527880 | — |
| 反応物 | 6-[4-(Benzyloxy)phenyl]-3-oxo-2,3,4,5-tetrahydropyridazine-4-carboxylic acid | HCID 69218872 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 生成物 | 6-Pyridin-2-yl-3-oxo-2,3,4,5-tetrahydropyridazine-4-carboxylic acid | HCID 69217260 | 96.2% |
反応手順
Working as in example 19 for the preparation of 6-[4-(benzyloxy)phenyl]-3-oxo-2,3,4,5-tetrahydropyridazine-4-carboxylic acid, but starting with 4 g of ethyl 6-pyridin-2-yl-3-oxo-2,3-dihydropyridazine-4-carboxylate, 49 cm3 of one molar sodium hydroxide solution and 50 cm3 of one molar hydrochloric acid solution, 3.44 g of 6-pyridin-2-yl-3-oxo-2,3,4,5-tetrahydropyridazine-4-carboxylic acid were obtained in the form of a beige-colored solid melting at a temperature above 260° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07462613B2 |
| 出典データセット | uspto-grants-2008_12 |
| ORD ID | ord-942ff03a60c84e49a074b9376cf4a383 |
| 出典メモ | uspto-grants-2008_12 |