Sulfuric Acid → 6-Chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid

HRID 2374781Notes

Reaction equation

HRID 2374781 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([Cl:11])=[CH:6][C:7]=1[C:8]([OH:10])=[O:9].S(=O)(=O)(O)[OH:13]>O>[Cl:11][C:5]1[CH:6]=[C:7]([C:8]([OH:10])=[O:9])[C:2](=[O:13])[NH:3][N:4]=1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 4338043,6-Dichloropyridazine-4-carboxylic acid

Product 1

HCID 3340156-Chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

27 g of 3,6-dichloro-pyridazine-4-carboxylic acid were stirred at 50° C. for 6 h in a. 1:1 mixture of concentrated sulphuric acid and water. The pure product crystallized after cooling off the reaction mixture and was filtered.

Workup

  1. customThe pure product crystallized
  2. temperatureafter cooling off the reaction mixture
  3. filtrationwas filtered

Sources & evidence

ORD record
ord-583302761fd24d96affe4d1266f0b4fd
Source dataset
uspto-grants-2008_12
Patent number
US07462613B2

Reaction notes

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