1,4-Dioxane hydrochloride → HCID 68418369, compound

HRID 2374819Notes

Reaction equation

HRID 2374819 reaction equation
[CH:1]1[C:11]2[CH:10]=[CH:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[C:6](=[C:16]3[CH2:21][CH2:20][N:19]([C:22]([C@@H:24]([N:29](C)[C:30](=O)OC(C)(C)C)[CH2:25][CH:26]([CH3:28])[CH3:27])=[O:23])[CH2:18][CH2:17]3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[ClH:38].O1CCOCC1>O1CCOCC1>[ClH:38].[CH:12]1[C:8]2[CH:9]=[CH:10][C:11]3[CH:1]=[CH:2][CH:3]=[CH:4][C:5]=3[C:6](=[C:16]3[CH2:17][CH2:18][N:19]([C:22]([C@@H:24]([NH:29][CH3:30])[CH2:25][CH:26]([CH3:27])[CH3:28])=[O:23])[CH2:20][CH2:21]3)[C:7]=2[CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 59853922HCID 59853922, compound

Product 1

HCID 68418369HCID 68418369, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

344 mg (0.69 mmol) of t-butyl (1S)-1-{[4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-piperidinyl]carbonyl}-3-methylbutyl(methyl)carbamate was dissolved in 2 ml of 1,4-dioxane. 4 ml of 4 N hydrochloric acid/1,4-dioxane solution was added to the obtained solution, and they were stirred at room temperature for 5 hours and then concentrated under reduced pressure to obtain the title compound.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-b0018832a0e54aaaa758b64f7c60d373
Source dataset
uspto-grants-2008_12
Patent number
US07462630B2

Reaction notes

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