(S)-Methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetate → Methyl 2-((S)-6-((R)-7-fluoro-4-(4-iodo-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

HRID 237484Notes

Reaction equation

HRID 237484 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]2[C:17]([CH3:18])=[CH:16][C:15]([I:19])=[CH:14][C:13]=2[CH3:20])=[C:6]2[C:10]=1[C@@H:9]([OH:11])[CH2:8][CH2:7]2.O[C:22]1[CH:35]=[CH:34][C:25]2[C@H:26]([CH2:29][C:30]([O:32][CH3:33])=[O:31])[CH2:27][O:28][C:24]=2[CH:23]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]2[C:13]([CH3:20])=[CH:14][C:15]([I:19])=[CH:16][C:17]=2[CH3:18])=[C:6]2[C:10]=1[C@H:9]([O:11][C:22]1[CH:35]=[CH:34][C:25]3[C@H:26]([CH2:29][C:30]([O:32][CH3:33])=[O:31])[CH2:27][O:28][C:24]=3[CH:23]=1)[CH2:8][CH2:7]2

Participants

3

Reactant 2

HCID 53393313(S)-Methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetateHCID 86697150(S)-7-fluoro-4-(4-iodo-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-ol

Product 1

HCID 86697149Methyl 2-((S)-6-((R)-7-fluoro-4-(4-iodo-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

Procedure

The title compound is prepared from (S)-7-fluoro-4-(4-iodo-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-ol and (S)-methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetate following a procedure analogous to that described in Step 3 of Intermediate 1. LC (method 8): tR=1.08 min; Mass spectrum (ESI+): m/z=595 [M+Na]+.

Sources & evidence

ORD record
ord-735ea0b31c7a48ff94c9117530c22adc
Source dataset
uspto-grants-2014_02
Patent number
US08642585B2

Reaction notes

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