Phosphorus oxychloride → HCID 11179346, compound

Participants

Reaction Steps

In a similar manner as described for Example 1, 2-[(2,2-dimethylpropanoyl)amino]-N-(1-{3-[(3,4,5-trimethoxyphenyl)amino]-1,2,4-triazin-6-yl}ethyl)benzamide (Intermediate 15) (0.040 g, 0.080 mmol) in 1,2-dichloroethane (10 mL) and phosphorus oxychloride (0.060 mL, 0.64 mmol) gave 2,2-dimethyl-N-(2-{5-methyl-2-[(3,4,5-trimethoxyphenyl)amino]-imidazo[5,1-f][1,2,4]triazin-7-yl}phenyl)propanamide (0.0039 g) as a yellow solid. 1H NMR (CDCl3): δ8.87 (s, 1H), 8.66 (dd, J=8.6, 1.2 Hz, 1H), 8.62 (dd, J=8.1, 1.6 Hz, 1H), 7.43-7.37 (m, 1H), 7.16-7.11 (m, 1H), 6.98 (s, 1H), 6.90 (s, 1H), 6.87 (s, 2H), 3.84 (s, 3H), 3.77 (s, 6H), 2.62 (s, 3H), 1.34 (s, 9H). MS m/z 491 (M+1).

Provenance & Evidence